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CBD Oil And Antibiotics: Is It Safe To Use Them Together?

As we all know, CBD oil is a useful remedy for many ailments and can provide you with relief from most of them. May it be heart health, brain health, or chronic pain, CBD can be useful for all. However, CBD may interact with certain drugs if not taken adequately.

Antibiotics are pretty common and are useful to treat numerous infections. CBD is equally advantageous to treat different infections as well.

Thus, in this article, I am going to discuss CBD, Antibiotics, its interaction with antibiotics, side effects as well as other drug interactions

What is CBD Oil: A Brief Idea

CBD oil is a naturally extracted oil which contains a concentration of cannabinoids within it, thus providing therapeutic benefits in several diseases.

It is often preferred because the content of THC in CBD oil is around 0.3% and thus it does not produce any psychoactive effect on consumption.

What is Antibiotics: Overview

Antibiotics are the most commonly used medications used for certain bacterial influenced ailments as it has the property to inhibit the growth of microorganisms. It is one of the well-known antibacterial agents that is helpful for fighting certain bacterial infections.

How does CBD Oil Work: Working Principle of CBD Oil

CBD works by influencing the endocannabinoid system with the use of neurotransmitters called cannabinoids. Well, our body has the potency to naturally produce these chemicals and indirectly stimulates the neurons.

Thus, after this, it produces an array of sensations as well as many medicinal benefits.

How Antibiotic Works: Working Principle of Antibiotics

Antibiotics have the same working principle as that of bacterial cells. That is, it provides us the same protection that bacteria provides from different diseases.

Antibiotics have cell wall whereas human cells do not have any cell wall. Thus, when you consume penicillin, it does not let the bacteria from any cell wall. Apart from that, intaking antibiotics can also slow protein building as well as DNA copying.

Are CBD and Marijuana the Same – Can it Make you High?

Well, CBD and marijuana are not the same. And, consuming CBD won’t make you high. However, it is important to keep one thing mind, it is better to consume it under healthcare professionals, who are successful in this sector.

THC in marijuana is responsible for making a person high. CBD is responsible for getting rid of the ailments and provides a helpful effect on a person’s health.

Thus, CBD and marijuana are both different, as Marijuana incorporates a high amount of THC within it and CBD does not.

CBD and Antibiotic: Research Study

There is no such significant evidence on consuming CBD with antibiotics, but we can understand it in this way. Well, antibiotics are processed by the liver through a family of an enzyme called P450.

To metabolize CBD, this enzyme P450 is used. And, this is the reason why CBD may interact with antibiotics.

 CBD has the same effect on P450 enzymes as grapefruit. Sometimes when you take certain medications, you are not allowed to consume grapefruit. P450 enzymes are the reason why this happens.

CBD is a stronger P450 enzyme inhibitor than grapefruit. And thus, CBD and Antibiotics need to be nicely researched before taking it together.

Are all Antibiotics Broken the Same Way?

Now, one question may arise in your mind. Are all antibiotics broken this way? Well, the answer to this question is No. Only Macrolide Antibiotics are broken by the enzyme P450.

So, these are the ones a person has to think before taking with CBD oil. Macrolide Antibiotics are the kind of antibiotics which people uses for certain conditions like respiratory tract as well as a skin infection.

Here are some of the examples:

  • Azithromycin
  • Clarithromycin
  • Erythromycin
  • Spiramycin
  • Telithromycin

Side Effects of CBD Oil

CBD oil is a very easy way to consume CBD and provides additional medicinal benefits to a particular individual. However, there are certain side effects that may trigger on consuming CBD oil orally or applying it on the affected area.

Here, I have listed some of them below:

  • Anxiety and Stress
  • Appetite changes
  • Mood Swings
  • Diarrhoea or Digestive Problems
  • Dizziness or Lightheadedness
  • Drowsiness
  • Dry mouth or Increased Thirst
  • Nausea and Vomiting

These side effects are comparatively milder and do not affect a person much. However, it is important to consume CBD oil under a health care professional or professional doctor who has experience in this sector to avoid these side effects. 

Is Taking CBD and Antibiotics Together a Cause of Concern?

If you want to take CBD and Antibiotics make sure you are not on Macrolide Antibiotics. These antibiotics are mainly for skin infections or respiratory infections.

As mentioned earlier, Macrolide Antibiotics are the kind of antibiotics that may interact with CBD and cause complications.

Can you Take CBD with Antibiotics?

Well, if you want to take CBD with Antibiotics, it is important to consult a healthcare professional who is successful in this sector.

He/she will give detailed information and any potential drug to drug interactions that may get triggered on its use.

Other Medications that May Interact with CBD Oil

CBD oil is an easy way to utilize cannabis and can provide your relief from various ailments. However,  CBD can interact with different drugs other than antibiotics as well.

Thus, it is important to ask a doctor and fix the dosage of all the drugs that you are taking for some other ailments.

This is because it may interact with CBD oil on consumption. Here, I have listed some of the drug interactions below. These are the drugs that might interact with CBD oil:

  • Clobazam
  • Valproic acid
  • Eslicarbazepine
  • Steroids
  • HMG CoA reductase inhibitors
  • Calcium channel blockers
  • Antihistamines
  • Prokinetics
  • HIV antivirals
  • Immune modulators
  • Benzodiazepines
  • Antiarrhythmics
  • Antibiotics
  • Anaesthetics
  • Antipsychotics
  • Antidepressants
  • Anti-epileptics
  • Beta-blockers
  • PPIs
  • NSAIDs
  • Angiotensin II blockers
  • Oral hypoglycemic agents
  • Sulfonylureas

Apart from that, CBD oil may also interact with certain edibles like grapefruit. So, If you are on certain medicinal herbs, it is better to consult a health care professional before taking CBD with it. 


If you are planning on to consume CBD oil, there are certain things that should be kept in mind.

People who are on blood thinning medication like aspirin should avoid consuming CBD in any form, as it may thin the blood more and cause excessive bleeding.

 Apart from that, if you have any surgery scheduled in one month, it is better to avoid CBD as it might thin the blood in such cases as well and cause excessive blood loss.

Also, if you are a lactating or pregnant mother, it is recommended not to consume CBD oil. It may affect both the mother as well as the baby and cause complications during the delivery process.

 It is important to see if you are allergic to CBD oil, as it may trigger certain side effects if you are allergic to CBD on consumption.

Lastly, make sure to consult a health care professional before consuming CBD as it may trigger certain drug interactions as well as side effects. 

Concluding the Forum

CBD oil is an easy way to consume CBD and has quite a potent role in today’s world. Thus, you can consume CBD in any form and get the best results. However, CBD in oil form can provide you with relief from all types of diseases without any issue.

Incorporating CBD in your diet with other drugs may trigger certain drug to drug interactions. As we all know, virals and infections are pretty common nowadays.

While both CBD and Antibiotic can provide an anti-bacterial effect to a person on consumption.

However, the most common question related to it is whether it can both be taken together or not? The answer to this question is quite complex. If you are on Macrolide Antibiotics, it is better to avoid using CBD along with it as it breaks the enzyme P450 enzyme.

Lastly, CBD oil has certain other drug interaction as well as side effects on consumption. Thus, it is better to consult a doctor who is well recognized in this sector